![]() ![]() These reference sequences are curated independently of the genomeĪnnotation cycle, so their versions may not match the RefSeq versions in the current These reference sequences exist independently of genome builds. See citations in PubMed for homologs of this gene provided by HomoloGene Biochim Biophys Acta Mol Cell Res, 2017 Dec. Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of α(1A)-adrenergic receptors.Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma.Probing the correlation between ligand efficacy and conformational diversity at the α(1A)-adrenoreceptor reveals allosteric coupling of its microswitches.Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese.Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes.Expression Biased expression in fat (RPKM 3.7), liver (RPKM 3.6) and 6 other tissues See more Orthologs mouse all NEW Try the new Gene table Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. ![]() This gene encodes alpha-1A-adrenergic receptor. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells. Full Name adrenoceptor alpha 1A provided by HGNC Primary source HGNC:HGNC:277 See related Ensembl:ENSG00000120907 MIM:104221 AllianceGenome:HGNC:277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as ADRA1C ADRA1L1 ALPHA1AAR Summary Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. ![]()
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